MiR-520d-3p suppresses the proliferation and epithelial-mesenchymal transition of cervical cancer cells by targeting ZFP36L2

MiR-520d-3p has recently been reported to have anti-tumor function in several cancers, including glioma and gastric cancer. However, the biological its mechanism of action remain unclear cervical cancer (CC). In this study, we observed that miR-520d-3p expression was lowly expressed CC specimens compared with adjacent normal using reverse transcription quantitative PCR. Moreover, low correlated FIGO stage lymph node metastasis by Chi-square test. Functionally, overexpression suppressed proliferation migration invasion two cell lines (HeLa SiHa) CCK-8 assay wound healing assay. After target prediction, luciferase reporter showed zinc finger protein 36 ring protein‐like 2 (ZFP36L2) a direct cells. The levels ZFP36L2 at mRNA were significantly increased tissues tissues. negatively patients CC. Importantly, abolished effects on proliferation, EMT process conclusion, our findings indicate targeting miR-520d-3p/ZFP36L2 axis might be promising therapeutic for treatment.